"Young researchers aspire to explain the world and fix its problems — but they are increasingly finding their ambitions thwarted. The challenge comes from the scientific enterprise itself. Grants and permanent positions are scarce, and administrative burdens can be crushing. Scientists, when judged on steady funding or publication streams, pursue projects that are certain to produce a ‘publishable unit’ even if they do not address big questions. Ultimately, this is bad for science and scientists alike."